Preliminary Assessment of the Safety and Immunogenicity of a New CTXΦ-Negative, Hemagglutinin/Protease-Defective El Tor Strain as a Cholera Vaccine Candidate

Vibrio cholerae 638 (El Tor, Ogawa), a new CTXΦ-negative hemagglutinin/protease-defective strain that is a cholera vaccine candidate, was examined for safety and immunogenicity in healthy adult volunteers. In a double-blind placebo-controlled study, no significant adverse reactions were observed in...

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Hlavní autoři: Benítez, Jorge A., García, Luis, Silva, Anisia, García, Hilda, Fando, Rafael, Cedré, Barbara, Pérez, Antonio, Campos, Javier, Rodríguez, Boris L., Pérez, José L., Valmaseda, Tania, Pérez, Oliver, Pérez, Alberto, Ramírez, Margarita, Ledón, Talena, Jidy, Manuel Díaz, Lastre, Miriam, Bravo, Laura, Sierra, Gustavo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 1999
Témata:
Microbial Immunity and Vaccines
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC96352/
https://ncbi.nlm.nih.gov/pubmed/9916056
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