Inactivation of the inhA-Encoded Fatty Acid Synthase II (FASII) Enoyl-Acyl Carrier Protein Reductase Induces Accumulation of the FASI End Products and Cell Lysis of Mycobacterium smegmatis

The mechanism of action of isoniazid (INH), a first-line antituberculosis drug, is complex, as mutations in at least five different genes (katG, inhA, ahpC, kasA, and ndh) have been found to correlate with isoniazid resistance. Despite this complexity, a preponderance of evidence implicates inhA, wh...

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Autores principales: Vilchèze, Catherine, Morbidoni, Hector R., Weisbrod, Torin R., Iwamoto, Hiroyuki, Kuo, Mack, Sacchettini, James C., Jacobs, William R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2000
Materias:
Genetics and Molecular Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC94593/
https://ncbi.nlm.nih.gov/pubmed/10869086
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