Staphylococcus aureus Mutants Isolated via Exposure to Nonfluorinated Quinolones: Detection of Known and Unique Mutations

The in vitro development of resistance to the new nonfluorinated quinolones (NFQs; PGE 9262932, PGE 4175997, and PGE 9509924) was investigated in Staphylococcus aureus. At concentrations two times the MIC, step 1 mutants were isolated more frequently with ciprofloxacin and trovafloxacin (9.1 × 10(−8...

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Main Authors: Roychoudhury, Siddhartha, Twinem, Tracy L., Makin, Kelly M., Nienaber, Mark A., Li, Chuiying, Morris, Timothy W., Ledoussal, Benoit, Catrenich, Carl E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2001
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC90847/
https://ncbi.nlm.nih.gov/pubmed/11709318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.12.3422-3426.2001
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