Unique Biological Properties and Molecular Mechanism of 5,6-Bridged Quinolones

We have characterized an early series of 5,6-bridged dioxinoquinolones which behaved strikingly different from typical quinolones. The 5,6-bridged dioxinoquinolones inhibited Escherichia coli DNA gyrase supercoiling activity but, unlike typical quinolones, failed to stimulate gyrase-dependent cleava...

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Detalhes bibliográficos
Main Authors: Macinga, David R., Renick , Paul J., Makin, Kelly M., Ellis, David H., Kreiner, Allison A., Li, Min, Rupnik, Kirk J., Kincaid, Erica M., Wallace, Cynthia D., Ledoussal, Benoit, Morris, Timothy W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC166059/
https://ncbi.nlm.nih.gov/pubmed/12878515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.8.2526-2537.2003
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