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Compartmental Pharmacokinetics and Tissue Distribution of the Antifungal Echinocandin Lipopeptide Micafungin (FK463) in Rabbits

The plasma pharmacokinetics and tissue distribution of the novel antifungal echinocandin-like lipopeptide micafungin (FK463) were investigated in healthy rabbits. Cohorts of three animals each received micafungin at 0.5, 1, and 2 mg/kg of body weight intravenously once daily for a total of 8 days. S...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Groll, Andreas H., Mickiene, Diana, Petraitis, Vidmantas, Petraitiene, Ruta, Ibrahim, Khalid H., Piscitelli, Stephen C., Bekersky, Ihor, Walsh, Thomas J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2001
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90832/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11709303/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.12.3322-3327.2001
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