In Vitro Activity of ABT-773 against Legionella pneumophila, Its Pharmacokinetics in Guinea Pigs, and Its Use to Treat Guinea Pigs with L. pneumophila Pneumonia

The activity of ABT-773 was studied against extracellular and intracellular Legionella pneumophila and for the treatment of guinea pigs with L. pneumophila pneumonia. The ABT-773 MIC at which 50% of isolates are inhibited (MIC(50)) for 20 different Legionella sp. strains was 0.016 μg/ml, whereas the...

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Autores principales: Edelstein, Paul H., Higa, F., Edelstein, Martha A. C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2001
Materias:
Experimental Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC90717/
https://ncbi.nlm.nih.gov/pubmed/11557455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.10.2685-2690.2001
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