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Novel α- and β-Amino Acid Inhibitors of Influenza Virus Neuraminidase

In an effort to discover novel, noncarbohydrate inhibitors of influenza virus neuraminidase we hypothesized that compounds which contain positively charged amino groups in an appropriate position to interact with the Asp 152 or Tyr 406 side chains might be bound tightly by the enzyme. Testing of 300...

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Publicado no:Antimicrob Agents Chemother
Principais autores: Kati, Warren M., Montgomery, Debra, Maring, Clarence, Stoll, Vincent S., Giranda, Vincent, Chen, Xiaoqi, Laver, W. Graeme, Kohlbrenner, William, Norbeck, Daniel W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2001
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90693/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11502530/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.9.2563-2570.2001
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