In Vitro Susceptibilities of Wild-Type or Drug-Resistant Hepatitis B Virus to (−)-β-d-2,6-Diaminopurine Dioxolane and 2′-Fluoro-5-Methyl-β-l-Arabinofuranosyluracil

Prolonged treatment of chronic hepatitis B virus (HBV) infection with lamivudine ([−]-β-l-2′,3′-dideoxy-3′ thiacytidine) or famciclovir may select for viral mutants that are drug resistant due to point mutations in the polymerase gene. Determining whether such HBV mutants are sensitive to new antivi...

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Bibliographic Details
Main Authors: Chin, Ruth, Shaw, Tim, Torresi, Joseph, Sozzi, Vittina, Trautwein, Christian, Bock, Thomas, Manns, Michael, Isom, Harriet, Furman, Phil, Locarnini, Stephen
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC90683/
https://ncbi.nlm.nih.gov/pubmed/11502520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.9.2495-2501.2001
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