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Resistance of Streptococcus pneumoniae to Deformylase Inhibitors Is Due to Mutations in defB
Resistance to peptide deformylase inhibitors in Escherichia coli or Staphylococcus aureus is due to inactivation of transformylase activity. Knockout experiments in Streptococcus pneumoniae R6x indicate that the transformylase (fmt) and deformylase (defB) genes are essential and that a def paralog (...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology
2001
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC90673/ https://ncbi.nlm.nih.gov/pubmed/11502510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.9.2432-2435.2001 |
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