Resistance of Streptococcus pneumoniae to Deformylase Inhibitors Is Due to Mutations in defB

Resistance to peptide deformylase inhibitors in Escherichia coli or Staphylococcus aureus is due to inactivation of transformylase activity. Knockout experiments in Streptococcus pneumoniae R6x indicate that the transformylase (fmt) and deformylase (defB) genes are essential and that a def paralog (...

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Dades bibliogràfiques

Publicat a:	Antimicrob Agents Chemother
Autors principals:	Margolis, Peter, Hackbarth, Corinne, Lopez, Sara, Maniar, Mita, Wang, Wen, Yuan, Zhengyu, White, Richard, Trias, Joaquim
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 2001
Matèries:	Mechanisms of Resistance
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90673/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11502510/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.9.2432-2435.2001
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