Resistance of Streptococcus pneumoniae to Deformylase Inhibitors Is Due to Mutations in defB

Resistance to peptide deformylase inhibitors in Escherichia coli or Staphylococcus aureus is due to inactivation of transformylase activity. Knockout experiments in Streptococcus pneumoniae R6x indicate that the transformylase (fmt) and deformylase (defB) genes are essential and that a def paralog (...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Margolis, Peter, Hackbarth, Corinne, Lopez, Sara, Maniar, Mita, Wang, Wen, Yuan, Zhengyu, White, Richard, Trias, Joaquim
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2001
Schlagworte:	Mechanisms of Resistance
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90673/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11502510/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.9.2432-2435.2001
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