Resistance of Streptococcus pneumoniae to Deformylase Inhibitors Is Due to Mutations in defB

Resistance to peptide deformylase inhibitors in Escherichia coli or Staphylococcus aureus is due to inactivation of transformylase activity. Knockout experiments in Streptococcus pneumoniae R6x indicate that the transformylase (fmt) and deformylase (defB) genes are essential and that a def paralog (...

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Detalhes bibliográficos
Main Authors: Margolis, Peter, Hackbarth, Corinne, Lopez, Sara, Maniar, Mita, Wang, Wen, Yuan, Zhengyu, White, Richard, Trias, Joaquim
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC90673/
https://ncbi.nlm.nih.gov/pubmed/11502510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.9.2432-2435.2001
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