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Aminoglycoside Resistance with Homogeneous and Heterogeneous Populations of Antibiotic-Resistant Ribosomes

Aminoglycosides bind to rRNA in the small subunit of the bacterial ribosome. Mutations in the decoding region of 16S rRNA confer resistance to specific subsets of aminoglycoside antibiotics. The two major classes of 2-deoxystreptamine aminoglycosides are the 4,5- and the 4,6-disubstituted antibiotic...

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Autori principali: Recht, Michael I., Puglisi, Joseph D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC90670/
https://ncbi.nlm.nih.gov/pubmed/11502507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.9.2414-2419.2001
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