Basis for prokaryotic specificity of action of aminoglycoside antibiotics.

The aminoglycosides, a group of structurally related antibiotics, bind to rRNA in the small subunit of the prokaryotic ribosome. Most aminoglycosides are inactive or weakly active against eukaryotic ribosomes. A major difference in the binding site for these antibiotics between prokaryotic and eukar...

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Main Authors: Recht, M I, Douthwaite, S, Puglisi, J D
Format: Artigo
Sprog:Inglês
Udgivet: 1999
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171394/
https://ncbi.nlm.nih.gov/pubmed/10357824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.11.3133
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