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Basis for prokaryotic specificity of action of aminoglycoside antibiotics.
The aminoglycosides, a group of structurally related antibiotics, bind to rRNA in the small subunit of the prokaryotic ribosome. Most aminoglycosides are inactive or weakly active against eukaryotic ribosomes. A major difference in the binding site for these antibiotics between prokaryotic and eukar...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
1999
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171394/ https://ncbi.nlm.nih.gov/pubmed/10357824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.11.3133 |
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