Heat Treatment of Amphotericin B Modifies Its Serum Pharmacokinetics, Tissue Distribution, and Renal Toxicity following Administration of a Single Intravenous Dose to Rabbits

The purpose of this investigation was to determine the serum pharmacokinetics, tissue distribution, and renal toxicity of amphotericin B (AmpB) following administration of a single intravenous dose (1 mg/kg of body weight) of Fungizone (FZ) and a heat-treated form of FZ (HFZ) to New Zealand White fe...

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Detalhes bibliográficos
Main Authors: Kwong, Evan H., Ramaswamy, Manisha, Bauer, Emily A., Hartsel, Scott C., Wasan, Kishor M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC90600/
https://ncbi.nlm.nih.gov/pubmed/11408223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.7.2060-2063.2001
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