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Heat Treatment of Amphotericin B Modifies Its Serum Pharmacokinetics, Tissue Distribution, and Renal Toxicity following Administration of a Single Intravenous Dose to Rabbits

The purpose of this investigation was to determine the serum pharmacokinetics, tissue distribution, and renal toxicity of amphotericin B (AmpB) following administration of a single intravenous dose (1 mg/kg of body weight) of Fungizone (FZ) and a heat-treated form of FZ (HFZ) to New Zealand White fe...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Kwong, Evan H., Ramaswamy, Manisha, Bauer, Emily A., Hartsel, Scott C., Wasan, Kishor M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2001
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90600/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11408223/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.7.2060-2063.2001
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