Plasma Protein Binding of Amphotericin B and Pharmacokinetics of Bound versus Unbound Amphotericin B after Administration of Intravenous Liposomal Amphotericin B (AmBisome) and Amphotericin B Deoxycholate

Unilamellar liposomal amphotericin B (AmBisome) (liposomal AMB) reduces the toxicity of this antifungal drug. The unique composition of liposomal AMB stabilizes the liposomes, producing higher sustained drug levels in plasma and reducing renal and hepatic excretion. When liposomes release their drug...

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Detalhes bibliográficos
Main Authors: Bekersky, Ihor, Fielding, Robert M., Dressler, Dawna E., Lee, Jean W., Buell, Donald N., Walsh, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC127463/
https://ncbi.nlm.nih.gov/pubmed/11850269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.3.834-840.2002
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