Multiple Mutations Modulate the Function of Dihydrofolate Reductase in Trimethoprim-Resistant Streptococcus pneumoniae

Trimethoprim resistance in Streptococcus pneumoniae can be conferred by a single amino acid substitution (I100-L) in dihydrofolate reductase (DHFR), but resistant clinical isolates usually carry multiple DHFR mutations. DHFR genes from five trimethoprim-resistant isolates from the United Kingdom wer...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Maskell, Jeffrey P., Sefton, Armine M., Hall, Lucinda M. C.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Mechanisms of Resistance
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90431/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11257022/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.4.1104-1108.2001
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