Multiple Mutations Modulate the Function of Dihydrofolate Reductase in Trimethoprim-Resistant Streptococcus pneumoniae

Trimethoprim resistance in Streptococcus pneumoniae can be conferred by a single amino acid substitution (I100-L) in dihydrofolate reductase (DHFR), but resistant clinical isolates usually carry multiple DHFR mutations. DHFR genes from five trimethoprim-resistant isolates from the United Kingdom wer...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Maskell, Jeffrey P., Sefton, Armine M., Hall, Lucinda M. C.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2001
Assuntos:	Mechanisms of Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90431/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11257022/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.4.1104-1108.2001
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