Multiple Mutations Modulate the Function of Dihydrofolate Reductase in Trimethoprim-Resistant Streptococcus pneumoniae

Trimethoprim resistance in Streptococcus pneumoniae can be conferred by a single amino acid substitution (I100-L) in dihydrofolate reductase (DHFR), but resistant clinical isolates usually carry multiple DHFR mutations. DHFR genes from five trimethoprim-resistant isolates from the United Kingdom wer...

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Bibliografski detalji
Glavni autori: Maskell, Jeffrey P., Sefton, Armine M., Hall, Lucinda M. C.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2001
Teme:
Mechanisms of Resistance
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC90431/
https://ncbi.nlm.nih.gov/pubmed/11257022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.4.1104-1108.2001
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