Relationships of the Area under the Curve/MIC Ratio to Different Integral Endpoints of the Antimicrobial Effect: Gemifloxacin Pharmacodynamics in an In Vitro Dynamic Model

Most integral endpoints of the antimicrobial effect are determined over an arbitrarily chosen time period, such as the dosing interval (τ), regardless of the actual effect duration. Unlike the τ-related endpoints, the intensity of the antimicrobial effect (I(E)) does consider its duration—from time...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Firsov, Alexander A., Lubenko, Irene Y., Portnoy, Yury A., Zinner, Stephen H., Vostrov, Sergey N.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2001
Témata:	Pharmacology
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90395/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11181382/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.3.927-931.2001
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