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Pharmacokinetics and Pharmacodynamics of Gatifloxacin against Streptococcus pneumoniae and Staphylococcus aureus in a Granulocyte-Rich Exudate

The pharmacokinetics of gatifloxacin were assessed in serum and in skin blister fluid (SBF), as was the pharmacodynamic activity in SBF. Five hours after a single dose of gatifloxacin, SBF killed 2.5 logs of Streptococcus pneumoniae and 1.5 log of Staphylococcus aureus during a 2-h incubation ex viv...

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Bibliografiske detaljer
Main Authors: Trampuz, Andrej, Laifer, Gerd, Wenk, Markus, Rajacic, Zarko, Zimmerli, Werner
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2002
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC128756/
https://ncbi.nlm.nih.gov/pubmed/12384378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.11.3630-3633.2002
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