Amino Acid Repetitions in the Dihydropteroate Synthase of Streptococcus pneumoniae Lead to Sulfonamide Resistance with Limited Effects on Substrate K(m)

Sulfonamide resistance in Streptococcus pneumoniae is due to changes in the chromosomal folP (sulA) gene coding for dihydropteroate synthase (DHPS). The first reported laboratory-selected sulfonamide-resistant S. pneumoniae isolate had a 6-bp repetition, the sul-d mutation, leading to a repetition o...

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Bibliographic Details
Published in:	Antimicrob Agents Chemother
Main Authors:	Haasum, Ylva, Ström, Katrin, Wehelie, Rahma, Luna, Vicki, Roberts, Marilyn C., Maskell, Jeffrey P., Hall, Lucinda M. C., Swedberg, Göte
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 2001
Subjects:	Mechanisms of Resistance
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90378/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11181365/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.3.805-809.2001
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Amino Acid Repetitions in the Dihydropteroate Synthase of Streptococcus pneumoniae Lead to Sulfonamide Resistance with Limited Effects on Substrate K(m)

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