Amino Acid Repetitions in the Dihydropteroate Synthase of Streptococcus pneumoniae Lead to Sulfonamide Resistance with Limited Effects on Substrate K(m)

Sulfonamide resistance in Streptococcus pneumoniae is due to changes in the chromosomal folP (sulA) gene coding for dihydropteroate synthase (DHPS). The first reported laboratory-selected sulfonamide-resistant S. pneumoniae isolate had a 6-bp repetition, the sul-d mutation, leading to a repetition o...

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Détails bibliographiques
Auteurs principaux: Haasum, Ylva, Ström, Katrin, Wehelie, Rahma, Luna, Vicki, Roberts, Marilyn C., Maskell, Jeffrey P., Hall, Lucinda M. C., Swedberg, Göte
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2001
Sujets:
Mechanisms of Resistance
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC90378/
https://ncbi.nlm.nih.gov/pubmed/11181365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.3.805-809.2001
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