Amino Acid Repetitions in the Dihydropteroate Synthase of Streptococcus pneumoniae Lead to Sulfonamide Resistance with Limited Effects on Substrate K(m)

Sulfonamide resistance in Streptococcus pneumoniae is due to changes in the chromosomal folP (sulA) gene coding for dihydropteroate synthase (DHPS). The first reported laboratory-selected sulfonamide-resistant S. pneumoniae isolate had a 6-bp repetition, the sul-d mutation, leading to a repetition o...

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Hlavní autoři: Haasum, Ylva, Ström, Katrin, Wehelie, Rahma, Luna, Vicki, Roberts, Marilyn C., Maskell, Jeffrey P., Hall, Lucinda M. C., Swedberg, Göte
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2001
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC90378/
https://ncbi.nlm.nih.gov/pubmed/11181365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.3.805-809.2001
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