Amino Acid Repetitions in the Dihydropteroate Synthase of Streptococcus pneumoniae Lead to Sulfonamide Resistance with Limited Effects on Substrate K(m)

Sulfonamide resistance in Streptococcus pneumoniae is due to changes in the chromosomal folP (sulA) gene coding for dihydropteroate synthase (DHPS). The first reported laboratory-selected sulfonamide-resistant S. pneumoniae isolate had a 6-bp repetition, the sul-d mutation, leading to a repetition o...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Haasum, Ylva, Ström, Katrin, Wehelie, Rahma, Luna, Vicki, Roberts, Marilyn C., Maskell, Jeffrey P., Hall, Lucinda M. C., Swedberg, Göte
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2001
Assuntos:	Mechanisms of Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90378/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11181365/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.3.805-809.2001
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