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High-Level Fluoroquinolone-Resistant Clinical Isolates of Escherichia coli Overproduce Multidrug Efflux Protein AcrA

Immunoblotting with antibody against AcrA, an obligatory component of the AcrAB multidrug efflux system, showed that this protein was overexpressed by ≥170% in 9 of 10 clinical isolates of Esherichia coli with high-level ciprofloxacin resistance (MICs, ≥32 μg/ml) but not in any of the 15 isolates fo...

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Main Authors: Mazzariol, Annarita, Tokue, Yutaka, Kanegawa, Tiffany M., Cornaglia, Giuseppe, Nikaido, Hiroshi
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2000
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC90220/
https://ncbi.nlm.nih.gov/pubmed/11083655
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