Phenotypic Characterization of pncA Mutants of Mycobacterium tuberculosis

We examined the correlation of mutations in the pyrazinamidase (PZase) gene (pncA) with the pyrazinamide (PZA) resistance phenotype with 60 Mycobacterium tuberculosis isolates. PZase activity was determined by the method of Wayne (L. G. Wayne, Am. Rev. Respir. Dis. 109:147–151, 1974), and the entire...

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Autors principals: Morlock, Glenn P., Crawford, Jack T., Butler, W. Ray, Brim, Suzanne E., Sikes, David, Mazurek, Gerald H., Woodley, Charles L., Cooksey, Robert C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2000
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC90060/
https://ncbi.nlm.nih.gov/pubmed/10952570
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