Phenotypic Characterization of pncA Mutants of Mycobacterium tuberculosis

We examined the correlation of mutations in the pyrazinamidase (PZase) gene (pncA) with the pyrazinamide (PZA) resistance phenotype with 60 Mycobacterium tuberculosis isolates. PZase activity was determined by the method of Wayne (L. G. Wayne, Am. Rev. Respir. Dis. 109:147–151, 1974), and the entire...

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Autori principali: Morlock, Glenn P., Crawford, Jack T., Butler, W. Ray, Brim, Suzanne E., Sikes, David, Mazurek, Gerald H., Woodley, Charles L., Cooksey, Robert C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2000
Soggetti:
Mechanisms of Resistance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC90060/
https://ncbi.nlm.nih.gov/pubmed/10952570
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