Phenotypic Characterization of pncA Mutants of Mycobacterium tuberculosis

We examined the correlation of mutations in the pyrazinamidase (PZase) gene (pncA) with the pyrazinamide (PZA) resistance phenotype with 60 Mycobacterium tuberculosis isolates. PZase activity was determined by the method of Wayne (L. G. Wayne, Am. Rev. Respir. Dis. 109:147–151, 1974), and the entire...

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Bibliografiske detaljer

Udgivet i:	Antimicrob Agents Chemother
Principais autores:	Morlock, Glenn P., Crawford, Jack T., Butler, W. Ray, Brim, Suzanne E., Sikes, David, Mazurek, Gerald H., Woodley, Charles L., Cooksey, Robert C.
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 2000
Fag:	Mechanisms of Resistance
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90060/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10952570/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.9.2291-2295.2000
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