Phenotypic Characterization of pncA Mutants of Mycobacterium tuberculosis

We examined the correlation of mutations in the pyrazinamidase (PZase) gene (pncA) with the pyrazinamide (PZA) resistance phenotype with 60 Mycobacterium tuberculosis isolates. PZase activity was determined by the method of Wayne (L. G. Wayne, Am. Rev. Respir. Dis. 109:147–151, 1974), and the entire...

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Detalhes bibliográficos
Main Authors: Morlock, Glenn P., Crawford, Jack T., Butler, W. Ray, Brim, Suzanne E., Sikes, David, Mazurek, Gerald H., Woodley, Charles L., Cooksey, Robert C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC90060/
https://ncbi.nlm.nih.gov/pubmed/10952570
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