Analysis of rdxA and Involvement of Additional Genes Encoding NAD(P)H Flavin Oxidoreductase (FrxA) and Ferredoxin-Like Protein (FdxB) in Metronidazole Resistance of Helicobacter pylori

Metronidazole (Mtz) is a critical ingredient of modern multidrug therapies for Helicobacter pylori infection. Mtz resistance reduces the effectiveness of these combinations. Although null mutations in a rdxA gene that encodes oxygen-insensitive NAD(P)H nitroreductase was reported in Mtz-resistant H....

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Kwon, Dong-Hyeon, El-Zaatari, Fouad A. K., Kato, Mototsugu, Osato, Michael S., Reddy, Rita, Yamaoka, Yoshio, Graham, David Y.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2000
Schlagworte:	Mechanisms of Resistance
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90025/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10898687/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.8.2133-2142.2000
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