Mutations in Plasmodium falciparum Cytochrome b That Are Associated with Atovaquone Resistance Are Located at a Putative Drug-Binding Site

Atovaquone is the major active component of the new antimalarial drug Malarone. Considerable evidence suggests that malaria parasites become resistant to atovaquone quickly if atovaquone is used as a sole agent. The mechanism by which the parasite develops resistance to atovaquone is not yet fully u...

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Main Authors: Korsinczky, Michael, Chen, Nanhua, Kotecka, Barbara, Saul, Allan, Rieckmann, Karl, Cheng, Qin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2000
Teme:
Mechanisms of Resistance
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC90020/
https://ncbi.nlm.nih.gov/pubmed/10898682
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