Selection of Cytochrome b Mutants Is Rare among Plasmodium falciparum Patients Failing Treatment with Atovaquone-Proguanil in Cambodia

Atovaquone-proguanil remains effective against multidrug-resistant Plasmodium falciparum in Southeast Asia, but resistance is mediated by a single point mutation in cytochrome b (cytb) that can arise during treatment. Among 14 atovaquone-proguanil treatment failures in a clinical trial in Cambodia,...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Lin, Jessica T., Waltmann, Andreea, Moser, Kara A., Park, Zackary, Na, Yu Bin, Aydemir, Ozkan, Brazeau, Nicholas F., Gosi, Panita, Marsh, Patrick W., Muller, Meredith S., Spring, Michele, Sok, Somethy, Bailey, Jeffrey A., Saunders, David L., Lon, Chanthap, Wojnarski, Mariusz
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092515/
https://ncbi.nlm.nih.gov/pubmed/33361308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01249-20
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