Selection of Cytochrome b Mutants Is Rare among Plasmodium falciparum Patients Failing Treatment with Atovaquone-Proguanil in Cambodia

Atovaquone-proguanil remains effective against multidrug-resistant Plasmodium falciparum in Southeast Asia, but resistance is mediated by a single point mutation in cytochrome b (cytb) that can arise during treatment. Among 14 atovaquone-proguanil treatment failures in a clinical trial in Cambodia,...

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Bibliografische gegevens
Gepubliceerd in:Antimicrob Agents Chemother
Hoofdauteurs: Lin, Jessica T., Waltmann, Andreea, Moser, Kara A., Park, Zackary, Na, Yu Bin, Aydemir, Ozkan, Brazeau, Nicholas F., Gosi, Panita, Marsh, Patrick W., Muller, Meredith S., Spring, Michele, Sok, Somethy, Bailey, Jeffrey A., Saunders, David L., Lon, Chanthap, Wojnarski, Mariusz
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2021
Onderwerpen:
Mechanisms of Resistance
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092515/
https://ncbi.nlm.nih.gov/pubmed/33361308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01249-20
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