Selection of Cytochrome b Mutants Is Rare among Plasmodium falciparum Patients Failing Treatment with Atovaquone-Proguanil in Cambodia

Atovaquone-proguanil remains effective against multidrug-resistant Plasmodium falciparum in Southeast Asia, but resistance is mediated by a single point mutation in cytochrome b (cytb) that can arise during treatment. Among 14 atovaquone-proguanil treatment failures in a clinical trial in Cambodia,...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Lin, Jessica T., Waltmann, Andreea, Moser, Kara A., Park, Zackary, Na, Yu Bin, Aydemir, Ozkan, Brazeau, Nicholas F., Gosi, Panita, Marsh, Patrick W., Muller, Meredith S., Spring, Michele, Sok, Somethy, Bailey, Jeffrey A., Saunders, David L., Lon, Chanthap, Wojnarski, Mariusz
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2021
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092515/
https://ncbi.nlm.nih.gov/pubmed/33361308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01249-20
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