BMS-232632, a Highly Potent Human Immunodeficiency Virus Protease Inhibitor That Can Be Used in Combination with Other Available Antiretroviral Agents

BMS-232632 is an azapeptide human immunodeficiency virus type 1 (HIV-1) protease (Prt) inhibitor that exhibits potent anti-HIV activity with a 50% effective concentration (EC(50)) of 2.6 to 5.3 nM and an EC(90) of 9 to 15 nM in cell culture. Proof-of-principle studies indicate that BMS-232632 blocks...

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Bibliographic Details
Main Authors:	Robinson, Brett S., Riccardi, Keith A., Gong, Yi-fei, Guo, Qi, Stock, David A., Blair, Wade S., Terry, Brian J., Deminie, Carol A., Djang, Fred, Colonno, Richard J., Lin, Pin-fang
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology 2000
Subjects:	Antiviral Agents
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC90019/ https://ncbi.nlm.nih.gov/pubmed/10898681
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BMS-232632, a Highly Potent Human Immunodeficiency Virus Protease Inhibitor That Can Be Used in Combination with Other Available Antiretroviral Agents

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