BMS-232632, a Highly Potent Human Immunodeficiency Virus Protease Inhibitor That Can Be Used in Combination with Other Available Antiretroviral Agents

BMS-232632 is an azapeptide human immunodeficiency virus type 1 (HIV-1) protease (Prt) inhibitor that exhibits potent anti-HIV activity with a 50% effective concentration (EC(50)) of 2.6 to 5.3 nM and an EC(90) of 9 to 15 nM in cell culture. Proof-of-principle studies indicate that BMS-232632 blocks...

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Autori principali: Robinson, Brett S., Riccardi, Keith A., Gong, Yi-fei, Guo, Qi, Stock, David A., Blair, Wade S., Terry, Brian J., Deminie, Carol A., Djang, Fred, Colonno, Richard J., Lin, Pin-fang
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2000
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC90019/
https://ncbi.nlm.nih.gov/pubmed/10898681
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