Interactions of Ofloxacin and Erythromycin with the Multidrug Resistance Protein (MRP) in MRP-Overexpressing Human Leukemia Cells

To investigate interactions between the multidrug resistance protein (MRP) and antimicrobial agents, we examined the effects of 12 agents on vincristine sensitivity and efflux of the calcein acetoxy-methyl ester (calcein-AM) of a MRP substrate in MRP-overexpressing cells. Only ofloxacin and erythrom...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Terashi, Kenji, Oka, Mikio, Soda, Hiroshi, Fukuda, Minoru, Kawabata, Shigeru, Nakatomi, Katsumi, Shiozawa, Ken, Nakamura, Takashi, Tsukamoto, Kazuhiro, Noguchi, Yuji, Suenaga, Mitsuhiro, Tei, Chuwa, Kohno, Shigeru
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2000
Schlagworte:	Pharmacology
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89936/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10817732/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.6.1697-1700.2000
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