Interactions of Ofloxacin and Erythromycin with the Multidrug Resistance Protein (MRP) in MRP-Overexpressing Human Leukemia Cells

To investigate interactions between the multidrug resistance protein (MRP) and antimicrobial agents, we examined the effects of 12 agents on vincristine sensitivity and efflux of the calcein acetoxy-methyl ester (calcein-AM) of a MRP substrate in MRP-overexpressing cells. Only ofloxacin and erythrom...

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Detalhes bibliográficos
Main Authors: Terashi, Kenji, Oka, Mikio, Soda, Hiroshi, Fukuda, Minoru, Kawabata, Shigeru, Nakatomi, Katsumi, Shiozawa, Ken, Nakamura, Takashi, Tsukamoto, Kazuhiro, Noguchi, Yuji, Suenaga, Mitsuhiro, Tei, Chuwa, Kohno, Shigeru
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC89936/
https://ncbi.nlm.nih.gov/pubmed/10817732
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