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Efficacy of FK463, a New Lipopeptide Antifungal Agent, in Mouse Models of Pulmonary Aspergillosis

The efficacy of FK463, a novel water-soluble lipopeptide, was evaluated in mouse models of pulmonary aspergillosis and was compared with that of amphotericin B (AMPH-B). In the pulmonary aspergillosis models induced by intranasal inoculation, FK463 exhibited good efficacy, with 50% effective doses i...

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Published in:Antimicrob Agents Chemother
Main Authors: Matsumoto, Satoru, Wakai, Yoshimi, Nakai, Toru, Hatano, Kazuo, Ushitani, Tomoe, Ikeda, Fumiaki, Tawara, Shuichi, Goto, Toshio, Matsumoto, Fumio, Kuwahara, Shogo
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2000
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89736/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10681328/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.3.619-621.2000
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