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Carrier-Mediated Delivery of 9-(2-Phosphonylmethoxyethyl)Adenine to Parenchymal Liver Cells: a Novel Therapeutic Approach for Hepatitis B

Our aim is to selectively deliver 9-(2-phosphonylmethoxyethyl)adenine (PMEA) to parenchymal liver cells, the primary site of hepatitis B virus (HBV) infection. Selective delivery is necessary because PMEA, which is effective against HBV in vitro, is hardly taken up by the liver in vivo. Lactosylated...

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Publicado no:Antimicrob Agents Chemother
Principais autores: de Vrueh, Remco L. A., Rump, Erik T., van de Bilt, Erika, van Veghel, Richard, Balzarini, Jan, Biessen, Erik A. L., van Berkel, Theo J. C., Bijsterbosch, Martin K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2000
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89714/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10681306/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.3.477-483.2000
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