In vivo fate of phosphorothioate antisense oligodeoxynucleotides: predominant uptake by scavenger receptors on endothelial liver cells.

Systemically administered phosphorothioate antisense oligodeoxynucleotides can specifically affect the expression of their target genes, which affords an exciting new strategy for therapeutic intervention. Earlier studies point to a major role of the liver in the disposition of these oligonucleotide...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Bijsterbosch, M K, Manoharan, M, Rump, E T, De Vrueh, R L, van Veghel, R, Tivel, K L, Biessen, E A, Bennett, C F, Cook, P D, van Berkel, T J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146893/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9241243/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.16.3290
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