In vivo fate of phosphorothioate antisense oligodeoxynucleotides: predominant uptake by scavenger receptors on endothelial liver cells.

Systemically administered phosphorothioate antisense oligodeoxynucleotides can specifically affect the expression of their target genes, which affords an exciting new strategy for therapeutic intervention. Earlier studies point to a major role of the liver in the disposition of these oligonucleotide...

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Bibliografische gegevens
Hoofdauteurs: Bijsterbosch, M K, Manoharan, M, Rump, E T, De Vrueh, R L, van Veghel, R, Tivel, K L, Biessen, E A, Bennett, C F, Cook, P D, van Berkel, T J
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1997
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC146893/
https://ncbi.nlm.nih.gov/pubmed/9241243
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