In vivo fate of phosphorothioate antisense oligodeoxynucleotides: predominant uptake by scavenger receptors on endothelial liver cells.

Systemically administered phosphorothioate antisense oligodeoxynucleotides can specifically affect the expression of their target genes, which affords an exciting new strategy for therapeutic intervention. Earlier studies point to a major role of the liver in the disposition of these oligonucleotide...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Bijsterbosch, M K, Manoharan, M, Rump, E T, De Vrueh, R L, van Veghel, R, Tivel, K L, Biessen, E A, Bennett, C F, Cook, P D, van Berkel, T J
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 1997
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC146893/
https://ncbi.nlm.nih.gov/pubmed/9241243
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