Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice.
We describe preliminary studies of the pharmacokinetics, biodistribution, and excretion of an oligodeoxy-nucleotide phosphorothioate ([S]oligonucleotide) in mice. After either intravenous or intraperitoneal administration of a single dose (30 mg/kg of body weight), [S]oligonucleotide (35S-labeled at...
Spremljeno u:
| Izdano u: | Proc Natl Acad Sci U S A |
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| Glavni autori: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
1991
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52348/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1881900/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.17.7595 |
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