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Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice.

We describe preliminary studies of the pharmacokinetics, biodistribution, and excretion of an oligodeoxy-nucleotide phosphorothioate ([S]oligonucleotide) in mice. After either intravenous or intraperitoneal administration of a single dose (30 mg/kg of body weight), [S]oligonucleotide (35S-labeled at...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Agrawal, S, Temsamani, J, Tang, J Y
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52348/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1881900/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.17.7595
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