Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice.

We describe preliminary studies of the pharmacokinetics, biodistribution, and excretion of an oligodeoxy-nucleotide phosphorothioate ([S]oligonucleotide) in mice. After either intravenous or intraperitoneal administration of a single dose (30 mg/kg of body weight), [S]oligonucleotide (35S-labeled at...

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Detalles Bibliográficos
Main Authors: Agrawal, S, Temsamani, J, Tang, J Y
Formato: Artigo
Idioma:Inglês
Publicado: 1991
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC52348/
https://ncbi.nlm.nih.gov/pubmed/1881900
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