In vivo fate of phosphorothioate antisense oligodeoxynucleotides: predominant uptake by scavenger receptors on endothelial liver cells.

Systemically administered phosphorothioate antisense oligodeoxynucleotides can specifically affect the expression of their target genes, which affords an exciting new strategy for therapeutic intervention. Earlier studies point to a major role of the liver in the disposition of these oligonucleotide...

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Detaylı Bibliyografya
Yayımlandı:	Nucleic Acids Res
Asıl Yazarlar:	Bijsterbosch, M K, Manoharan, M, Rump, E T, De Vrueh, R L, van Veghel, R, Tivel, K L, Biessen, E A, Bennett, C F, Cook, P D, van Berkel, T J
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Oxford University Press 1997
Konular:	Research Article
Online Erişim:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146893/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9241243/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.16.3290
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In vivo fate of phosphorothioate antisense oligodeoxynucleotides: predominant uptake by scavenger receptors on endothelial liver cells.

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