Role of the PDR Gene Network in Yeast Susceptibility to the Antifungal Antibiotic Mucidin

Yeast strains disrupted in the PDR1, PDR3, or PDR5 gene, but not in SNQ2, exhibited higher sensitivity to mucidin (strobilurin A) than did the isogenic wild-type strains. Different gain-of-function mutations in the PDR1 and PDR3 genes rendered yeast mutants resistant to this antibiotic. Mucidin indu...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Michalkova-Papajova, Dana, Obernauerova, Margita, Subik, Julius
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2000
Schlagworte:	Mechanisms of Action: Physiological Effects
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89695/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10639374/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.2.418-420.2000
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