Safety Assessment, In Vitro and In Vivo, and Pharmacokinetics of Emivirine, a Potent and Selective Nonnucleoside Reverse Transcriptase Inhibitor of Human Immunodeficiency Virus Type 1

Emivirine (EMV), formerly known as MKC-442, is 6-benzyl-1-(ethoxymethyl)-5-isopropyl-uracil, a novel nonnucleoside reverse transcriptase inhibitor that displays potent and selective anti-human immunodeficiency virus type 1 (HIV-1) activity in vivo. EMV showed little or no toxicity towards human mito...

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Détails bibliographiques
Auteurs principaux: Szczech, G. M., Furman, P., Painter, G. R., Barry, D. W., Borroto-Esoda, K., Grizzle, T. B., Blum, M. R., Sommadossi, J.-P., Endoh, R., Niwa, T., Yamamoto, M., Moxham, C.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2000
Sujets:
Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC89637/
https://ncbi.nlm.nih.gov/pubmed/10602732
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