Comparison of In Vitro Activities of Camptothecin and Nitidine Derivatives against Fungal and Cancer Cells

The activities of a series of camptothecin and nitidine derivatives that might interact with topoisomerase I were compared against yeast and cancer cell lines. Our findings reveal that structural modifications to camptothecin derivatives have profound effects on the topoisomerase I-drug poison compl...

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Main Authors: Del Poeta, Maurizio, Chen, Shih-Fong, Von Hoff, Daniel, Dykstra, Christine C., Wani, Mansukh C., Manikumar, Govindarajan, Heitman, Joseph, Wall, Monroe E., Perfect, John R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 1999
Fag:
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC89577/
https://ncbi.nlm.nih.gov/pubmed/10582872
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