Comparison of In Vitro Activities of Camptothecin and Nitidine Derivatives against Fungal and Cancer Cells

The activities of a series of camptothecin and nitidine derivatives that might interact with topoisomerase I were compared against yeast and cancer cell lines. Our findings reveal that structural modifications to camptothecin derivatives have profound effects on the topoisomerase I-drug poison compl...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Del Poeta, Maurizio, Chen, Shih-Fong, Von Hoff, Daniel, Dykstra, Christine C., Wani, Mansukh C., Manikumar, Govindarajan, Heitman, Joseph, Wall, Monroe E., Perfect, John R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Susceptibility
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89577/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10582872/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.12.2862
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