The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein.

Eitemau Tebyg

• Synergistic Antifungal Activities of Bafilomycin A(1), Fluconazole, and the Pneumocandin MK-0991/Caspofungin Acetate (L-743,873) with Calcineurin Inhibitors FK506 and L-685,818 against Cryptococcus neoformans
  gan: Del Poeta, Maurizio, et al.
  Cyhoeddwyd: (2000)
• Immunosuppressive and Nonimmunosuppressive Cyclosporine Analogs Are Toxic to the Opportunistic Fungal Pathogen Cryptococcus neoformans via Cyclophilin-Dependent Inhibition of Calcineurin
  gan: Cruz, M. Cristina, et al.
  Cyhoeddwyd: (2000)
• Rapamycin and Less Immunosuppressive Analogs Are Toxic to Candida albicans and Cryptococcus neoformans via FKBP12-Dependent Inhibition of TOR
  gan: Cruz, M. Cristina, et al.
  Cyhoeddwyd: (2001)
• One-step Heck Reaction Generates Nonimmunosuppressive FK506 Analogs for Pharmacological BMP Activation
  gan: Wang, Yuefan, et al.
  Cyhoeddwyd: (2019)
• Calcineurin is required for virulence of Cryptococcus neoformans.
  gan: Odom, A, et al.
  Cyhoeddwyd: (1997)