The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein.

類似資料

• Synergistic Antifungal Activities of Bafilomycin A(1), Fluconazole, and the Pneumocandin MK-0991/Caspofungin Acetate (L-743,873) with Calcineurin Inhibitors FK506 and L-685,818 against Cryptococcus neoformans
  著者:: Del Poeta, Maurizio, 等
  出版事項: (2000)
• Immunosuppressive and Nonimmunosuppressive Cyclosporine Analogs Are Toxic to the Opportunistic Fungal Pathogen Cryptococcus neoformans via Cyclophilin-Dependent Inhibition of Calcineurin
  著者:: Cruz, M. Cristina, 等
  出版事項: (2000)
• Rapamycin and Less Immunosuppressive Analogs Are Toxic to Candida albicans and Cryptococcus neoformans via FKBP12-Dependent Inhibition of TOR
  著者:: Cruz, M. Cristina, 等
  出版事項: (2001)
• One-step Heck Reaction Generates Nonimmunosuppressive FK506 Analogs for Pharmacological BMP Activation
  著者:: Wang, Yuefan, 等
  出版事項: (2019)
• Calcineurin is required for virulence of Cryptococcus neoformans.
  著者:: Odom, A, 等
  出版事項: (1997)