Decreased Antipyrine Clearance following Endotoxin Administration: In Vivo Evidence of the Role of Nitric Oxide

Klebsiella pneumoniae endotoxin has been found to decrease hepatic P450-mediated drug-metabolizing enzyme activity in a time-dependent manner. In this study, we investigated the role of nitric oxide (NO) in the decrease in hepatic drug-metabolizing enzyme activity caused by endotoxin in vivo. We mea...

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Main Authors: Kitaichi, Kiyoyuki, Wang, Li, Takagi, Kenji, Iwase, Mitsunori, Shibata, Eiji, Nadai, Masayuki, Takagi, Kenzo, Hasegawa, Takaaki
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 1999
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC89545/
https://ncbi.nlm.nih.gov/pubmed/10543749
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