Possible Mechanism by Which the Carbapenem Antibiotic Panipenem Decreases the Concentration of Valproic Acid in Plasma in Rats

There is evidence indicating that the carbapenem antibiotic panipenem decreases plasma concentrations of valproic acid (VPA) in epileptic patients during VPA therapy. The mechanism for panipenem-induced changes in the pharmacokinetics of VPA was investigated in rats with and without bile duct cannul...

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Bibliographic Details
Main Authors: Kojima, Saori, Nadai, Masayuki, Kitaichi, Kiyoyuki, Wang, Li, Nabeshima, Toshitaka, Hasegawa, Takaaki
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1998
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC106012/
https://ncbi.nlm.nih.gov/pubmed/9835504
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